Abaddon was among some of the first demons to fall, and was handpicked by Lucifer himself to become one of the Knights of Hell, the demon also possesses the unique ability to partially enter a person in the form of demon smoke in order to read their thoughts. Abaddon is possibly the last surviving member of the Knights, as the archangels were thought to have killed them all. While trying to obtain the Key to the Bunker of the Men of Letters, Abaddon massacred the Men of Letters group in Kansas. Larry Ganem, the last survivor of the Men of Letters, described her as a "hired gun," but did not say who was in control of her. Abaddon traveled to year 2013, while in pursuit of Henry Winchester and the Box, where she was eventually and temporarily incapacitated by the Winchesters.

Abaddon is also the only demon shown to date to express a particular attachment to a specific meatsuit beyond what they require; while Azazel, Crowley, Ruby, Meg and Lilith have manifested in the same vessel more than once, these encounters all featured them simply returning to pre-established surviving hosts, whereas Abaddon specifically restored Josie Sands to serve as her body where Meg and Ruby simply assumed new hosts after their original ones were killed.