Telling powerful stories, TLC follows medical journeys of morbidly obese people as they attempt to save their own lives. The featured individuals - each weighing more than 600 pounds - confront lifelong emotional and physical struggles as they make the courageous decision to undergo high-risk gastric bypass surgery. In addition to drastically changing their appearances, they hope to reclaim their independence, mend relationships with friends and family, and renew their feelings of self-worth.