Littlest Pet Shop follows Blythe Baxter, a teenage girl who, after moving into an apartment in a metropolitan area, gains the ability to communicate with animals. Located below her apartment is the eponymous pet store where Blythe works and talks to a group of pets who regularly reside at a day care in the shop. Worried that a corrupt rival business will drive their shop out of business, the pets depend on Blythe to bring business into the store with her pet fashion designs.