Hit and Miss follows Sevigny's Mia, a contract killer with a secret: she's a pre-op transsexual. Mia's life is sent into a tailspin when she receives a letter from an ex-girlfriend dying from cancer revealing that Mia fathered a son eleven years ago. Mia becomes the guardian to a new family, a choice that forces her to mix her killer instincts with her newly acquired maternal ones.

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