Isaac Mendez was an artist and comic book author living in Manhattan. He had a loft studio in Lower Manhattan. His art dealer and former girlfriend was Simone Deveaux. Isaac was addicted to heroin, although he had been through rehab twice. Many of his works of art are prophetic, accurately depicting events of the future. After he predicted his own death, Isaac was murdered by Sylar.

Urged on by his instructor, Dominick Cabalo, Isaac honed his art skills and took various summer classes to help develop his craft. It wasn't until high school when he began winning illustration contests. With even more classes in illustration and comic design courses under his belt, Isaac moved to New York and soon after high school took various courses in college for comic book illustration. It wasn't until the annual New York comic convention that he caught the eye of Camacho Comics and they hired him on the spot. He worked there for 3 years, all the while learning the ins and outs of the business. Then in 2002 he self-published his own line of comics under his old uncle Burk's name—one of the few people in his life who supported his love of comic books. (9th Wonders!, Issue #14)