Juliette Silverton is Nick's girlfriend who works as a veterinarian. She spent much of her childhood in Spain with her grandmother, and as a result is fluent in Castilian Spanish (though, her spoken accent is similar to that found in Latin America). Although Marie suggested that Nick should leave Juliette for her safety, Nick has decided to stay with her. He postponed his original plans to propose to her while he explores his new life as a Grimm. However, Nick decided to propose to Juliette, only for her to turn him down due to her feeling as though he is hiding something from her.

Juliette suffers a scratch while treating Adalind Schade's cat. When Nick reacts with horror, Juliette demands he tell her what's going on. Nick tries to explain by bring her to the trailer and then to Monroe, but Juliette falls unconscious and is taken to the hospital where she awakens with black eyes, her fate uncertain. She eventually awakens from her coma with a little help from a liquid made by Rosalee used as eye drops (made to try to stop any progressing memory loss, but not to actually wake her), and a potion prepared for and delivered by Renard. Unfortunately due to a spell, while she remembers everything else about her life, all memories of Nick specifically have been erased (To the point that she can remember Monroe despite having only met him through Nick). She has also begun to develop an unusual attraction to Captain Renard due to his role in awakening her, but fights this attraction due to her complicated relationship with Nick.

She drinks a potion with Captain Renard and Nick that is supposed to break the compulsive attraction to the captain. The compulsion is broken and but she starts hallucinating sounds and images, such as envisioning that the floor of her house had collapsed. She thinks she's going crazy, but is really regaining her memories of Nick. She begins seeing very clear visions of Nick, many copies all talking at once. It appears she is being overwhelmed by the recovering memories. To help her, she contacts the Mexican woman she met. She tells Juliette to concentrate in a single memory at a time to completely remember them.

She returns to the trailer by herself and remembers what Nick told her the first night she went there. Juliette convinces Monroe to reveal to her the truth of Grimms and the Wesen world, with Rosalee, Bud and Monroe wogeing in front of her to reveal the truth. From that point on, she starts to become increasingly interested in Nick's Grimm activities, even joining him in fighting zombies.