Daphne Moon Crane (born September 1961) is a fictional character on the American television sitcom Frasier, played by Jane Leeves.

Daphne is a recent immigrant from England who is employed by Frasier Crane as a live-in housekeeper and physical therapist for his father, Martin. Her quirky personality and claims of psychic abilities provided comic relief on the show, while her relationship with Frasier's brother Niles Crane was a major dramatic plotline during the run of the series, progressing from Niles' secret infatuation at the beginning of the show to their marriage at the beginning of season ten. The role was originally to be filled by Lisa Maxwell who left before production began due to a dispute with producers.

Like most characters on Frasier, Daphne has many eccentricities. She often tells rambling stories about her family, cheerfully remembering rather grim or traumatic events, to the considerable discomfort of the Crane family. She is also a firm believer in the supernatural, and believes herself to be "a bit psychic". Daphne's apparent psychic abilities are often treated with ambiguity on the show, and her various 'visions' are sometimes shown to have come true, sometimes in a roundabout way and sometimes very accurately. On the other hand, for the first seven seasons of the series, the supposedly psychic Daphne never suspects Niles' passionate infatuation with her, which is painfully evident to all the other main characters. (Indeed, she only finally learns of this when Frasier, in a tranquilized, drowsy state, tells her outright.) As the series progressed, Daphne's psychic abilities were considerably played down.