A forensic anthropologist, Dr. Temperance "Bones" Brennan and a cocky FBI agent, Seeley Booth are teamed together to investigate causes of death by focusing on human remains.
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You Should be more specific in what your asking because quite a few things happened to him.
3 things off the top of my head:
He was stuck by a needle containing a deadly toxin and almost died
His brother was deathly ill, he returned home to be with him and was arrested. But with the help of Jeffersonian team and Booth was Able to get out of that situation.
This season it appears he left the Jeffersonian for greener pastures. So sad