Dr. Clark Edison is a recurring character who first appeared in the Season 3 premiere where he tried to become Dr. Brennan's assistant in Zack's absence. However, Zack returned in that very episode. Clark returned twice more — the second third season episode "The Verdict in the Story", working with the defense of Brennan's father who was on trial for murder, actually proving one of Zach's conclusions about the murder weapon to be incorrect. In Episode 1 of the fourth season, "Yanks in the UK", he made an appearance as the first of the group of six revolving assistants assigned to replace Zack. At the end of the episode however, he reveals he cannot tolerate the informal attitudes of Dr. Brennan's team, and quits. He does retain a recurring role throughout the series, still harboring ill feelings towards the informal behavior of his co-workers even as he recognizes the Jeffersonian's exceptional reputation. In "The Girl in the Mask," Brennan compares Clark with Wendell and Vincent, saying Clark is the "most astute". Clark Edison is a vegan and so is his girlfriend.

In the fourth season finale, Clark was re-imagined as a rap musician ('C-Synch') hoping to play at Booth and Brennan's night club, 'The Lab'. Booth refused to book him because his brother (a re-imagined Grayson Barasa) was a gang leader.

In the sixth-season premiere it is revealed he left the Jeffersonian Institute for a position in Chicago. He rejoined Dr. Brennan's team in the second sixth-season episode, "The Couple in the Cave", after learning of her return to the Jeffersonian Institute.