Samantha Stephens is an American house-wife who is also a witch. She has a twitch in her nose that has always been her main characteristic when doing magic. In 1964 she married a mortal named Darrin Stephens. She wanted to have a normal life so she and Darrin made an agreement that she would never use witchcraft, just in emergency cases, and have an ordinary, "mortal", happy life. This was much to the dismay of her parents, Endora and Maurice, who don't like the fact, as they see it, that their daughter is rejecting her heritage. Samantha became the Queen of Witches in the fourth season of the series.

However, witchcraft always will be a part of the Stephens family as Samantha's family is always playing tricks on Darrin. Through the years Darrin would accept that magic always will be a part of Samantha.

Samantha and Darrin have a loving relationship, but they are always battling against people that want to break up their marriage. They have mutually learned to be a part of the other's world.

In 1965 Samantha gave birth to a daughter named Tabitha who inherited Samantha's magic powers and Darrin's character. No matter how much Samantha and Darrin tried to teach Tabitha not to use witchcraft, the little witch is always playing innocent magical games; encouraged by Endora.

In 1970 Samantha gave birth to a son named Adam who, like his sister, inherited their mother's magic powers and their father's character. Like his sister, he was encouraged to use witchcraft by Endora, much to the dismay of Samantha and Darrin.

Samantha is very beautiful. She has large green eyes, silky and sleek blonde hair that is nearly shoulder-length. She is petite but tall for a woman. Samantha is a slender woman with a nice figure. Samantha also has slender, skinny hands and an upturned nose.

Samantha is the only character to appear in every episode of the series.