Grey Matter's small size belies his great calculative and technical intellect. He can create complicated machines from spare parts, understand the function of any device at a glance, and make sophisticated repairs to complex machines, (such as a warp-drive engine). Grey Matter's intellect serves as a problem solver and analytical help in difficult situations. This allows Grey Matter to think more strategically when brute force is inefficient.

Grey Matter can sometimes manipulate living things by stimulating certain parts of their nervous system, if such beings can be controlled by external stimuli.

Grey Matter's size allows him to squeeze into small spaces and can climb walls due to tiny suction cups on his skin. He also has sharp teeth and his slimy skin makes him difficult to grab.

Grey Matter appears to be stronger than he looks, as he was strong enough to move a cleaner's bucket with mops in it in Ultimate Weapon, and in So Long, and Thanks for All the Smoothies, he was able to break a coolant pipe to freeze the Vreedle Brothers.

According to Derrick J. Wyatt, Grey Matter is amphibious and has gills.

Grey Matter has a long prehensile tongue, owing to his insectivore nature. As a Galvan, he also possesses a 'pre-brain' which deals with all basic bodily functions.

Grey Matter was able to understand Pyxi's speech in Rad.