Agent X centers on America’s first female Vice President, Maccabee, a woman with brains, beauty, and a cool composure. After the death of her husband, a Senate candidate, Natalie opted to run in his place, and after a rapid political rise, she now finds herself the newly elected Vice President of the United States. She soon learns that it comes with a top secret duty: protecting the Constitution in times of great crisis with the aid of her secret operative designated “Agent X”.