Absentia centers on an FBI agent Emily Byrne, (Stana Katic) who, while hunting one of Boston’s most notorious serial killers, disappears without a trace and is declared dead. Six years later, she is found in a cabin in the woods, barely alive and with no memory of the years she was missing. Returning home to learn her husband (Heusinger) has remarried and her son is being raised by another woman, she soon finds herself implicated in a new series of murders.