The show often did cross over episodes with characters from Cheers.
The aircraft in the opening and closing credits (N121PP) is still in use with Cape Air Airlines of Hyannis, Massachusetts. One of Cape Air's primary destinations in its New England operation (they also operate in Florida, the Caribbean, and Micronesia) is, in fact, Nantucket. This particular aircraft exclusively serves the New England market, so on any given day it is probably flying in and out of Nantucket. When filmed for the credits, 121PB was in the livery of the now-defunct Express Air of New Bedford, Massachusetts. Shortly after the filming, it became the property of Cape Air and has been used in that airline's service ever since. Prior to Express Air, it was in service for Provincetown-Boston Airlines (hence the PB in the registration), which went out of business the year before Cape Air started.
The show's theme music is a shortened version of the Rondo from "Piano Sonata in A Major" by Franz Schubert.
There is a Tom Nevers Field on Nantucket, but it's not the airport, it's a sports complex. The airport on Nantucket is Nantucket Memorial Airport.
Tony Shalhoub's father and mother's names are Joe and Helen, matching the two lead characters in "Wings". Additionally, his father's brother's name is Brian, the same as the show's character Joe. Coming from a NY theatre background and unfamiliar with the then year old program, Shalhoub was unaware of this until he saw his audition script.
Roy was born on February 29, 1948.
The character name Carlton Blanchard, played by William Hickey (I), was taken from a character in the movie Wings, where he was played by William Hickey (II) (II). (Coincidentally, William Hickey (I), who appeared in this series, was born the year the movie was released.)
The Club Car, which was often featured on the show, is a real restaurant on Nantucket.
The license number of Sandpiper's plane, N121-PP, always used the call sign "Cessna Nevada 1-2-1 Papa Papa" when referred to on the radio.
Five characters from Cheers; Norm, Cliff, Frasier, Lillith and Rebecca, made appearances on the show. No characters from Wings crossed over to any Cheers episodes, though Thomas Haden Church played an unrelated character on a Cheers episode prior to being cast on Wings.
Prior to joining the cast as Antonio, Tony Shalhoub had played an unnamed waiter in an earlier episode. In an episode featuring clips from that appearance, Antonio said he worked as a waiter when he first arrived on Nantucket.
Thomas Haden Church left the series when cast in the FOX Sitcom Ned and Stacey. Lowell was written off by having him enter the Witness Protection Program after he saw a Mob hit. Brian Haley replaced Church as new mechanic Budd Bronski, but was written out of the series without explanation after only one season.
Casey's ex-husband Stuart appeared in one episode, and was played by John Ritter, who would later marry Amy Yasbeck.
Kevin Conroy was considered for the part of Joe. Conroy would soon go on to do the voice of Batman in the 1990's animated series and related projects. Tim Daly would go on to provide the voice of Superman in a crossover/companion series related to Conroy's Batman projects.
In one episode, Helen is watching home movies of one of her childhood birthday parties. Young Brian is seen wearing a T-Shirt saying "STAR TREK LIVES". Steven Weber would later guest star on an episode of Star Trek: Deep Space Nine, and Tim Daly's father James Daly guest starred on the original Star Trek: The Original Series series. The "Star Trek" series, like "Wings", were all produced by Paramount Television (the original series began as a Desilu production).
All of 'Fay Evelyn Schlob Dumbly DeVay Cochran's' ex-husbands are named George.
Lowell's first and last name (Mather) came from the names of two Harvard University halls.
Lowell states that Helen's birthday is the same as the anniversary of the date Sir John Speke discovered the source of the Nile. That would make her birthday July 28th.
First and only time we see the airfields control tower from the inside. One of the very rare times we see an air traffic controller and is identified by name, Walter.
The movie Brian wants to watch is _Shogun (1980)_, which was filmed in the '80s in color. However on the screen it appears to be black and white with large amounts of dust and blotches, indicating its supposed to be a much older film.
The episode, "My Brother's Keeper", was the first time that Timothy Daly and his sister Tyne Daly co-starred in a production together. They've done this three times- this episode, the 1999 television movie Execution of Justice (1999) (TV), and an episode of Judging Amy.
Mimsy's character is named after a passage from the Lewis Carroll poem Jabberwocky - "All mimsy were ye borogoves".
Faye has a streak of touching every First Lady of the United States from Elanor Roosevelt to Barbara Bush. She had to hurdle a barbecue pit to touch Lady Bird Johnson, she accidentally knocked Pat Nixon down, and Nancy Reagan told her to get out of her face or she'd have her arrested.
At the end of this episode, Joe refers to Lilith Crane as "Morticia." Bebe Neuwirth, who played Lilith, later originated the role of Morticia in the 2010 Broadway musical "The Addams Family."
Tony Shalhoub's character, Antonio Scarpacci, is accused of being a Lebanese terrorist. Shaloub is in fact half Lebanese. His father emigrated from Lebanon at the age of ten.
We learn Roy sneezes like a little baby.
We learn Lowell speaks fluent French, and also likes to drop names at restaurants.
The clapperboard for the Sandpiper Air Commercial indicate the following: Director: Lenny Garner (a.k.a. 'Leonard R. Garner Jr'; Camera: Jerry Workman. Garner and Workman were director and cinematographer of the episode, respectively.
The five performers as the Brady Kids also played these roles in The Brady Bunch Movie, which hit theaters around the same time this episode played.