4x18 No Regrets
First Aired: Apr. 18, 2017 on ABC
Summary: The truth behind Fitz’s turn could bring down all of S.H.I.E.L.D.,
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Leo Fitz: Beaten to within an inch of her life - nevertheless, she persisted.
- During the commercials before the credits of the episode, an advertising of L'Oreal Hydra Genius Liquid Care, a blue liquid soap, was aired.
- The plaque that agent May reads at HYDRA headquarters says: "IN REMEMBRANCE OF The two hundred seventy-nine innocent souls who lost their lives in The Cambridge Incident. While they perished at the hands of evil, the fight for justice will go on forever in their names."
- David O'Hara plays Fitz's father. He also played a character named Fitzy in The Departed.
- SPOILER: The composition of the super serum used by Melinda May in the Framework is the same than the one used by Calvin Zabo in the real world to get his super strength. Coincidentally the improved version of same serum was used in Project Patriot which gave Jeffrey Mace his powers in the real world.