4x16 What If...
First Aired: Apr. 04, 2017 on ABC
Summary: Hail the New World Order! Daisy and Simmons uncover secrets and lies in a world gone mad. With Hydra in control, they are our only hope to save everyone in the world.
- This is Brett Dalton's first episode on the show since the season 3 finale with his portrayal of Hive.
- The title of the episode is a reference to the Marvel comic series What If? Comic Books. The series took significant events from the Marvel Universe and speculate about what might have happened if it had had a different outcome. Each issue offers a look at characters we know in situations they might never really face.