In the premiere episode of season 8, Niles takes a mobile phone call. After a pause, he says, "No, there is no Wendell Vaughn here." Wendell Vaughn is the real name of the Marvel Comics superhero Quasar.
The two final choices for the role of Roz were Peri Gilpin and Lisa Kudrow. Kudrow was originally cast because her line readings were funnier. But during rehearsals, the show's creators felt that Kudrow lacked the forcefulness needed to play Roz and she was replaced with Gilpin.
David Hyde Pierce's Niles Crane is a stuffy milquetoast with a mad passion for his father's live-in therapist. In his previous series, The Powers That Be, he played a stuffy milquetoast with a mad passion for the maid.
Niles' wife Maris is never seen (at least her face) or heard from in the entire series. The same thing is mentioned about Vera, the wife of Norm Petersen in Cheers. We only hear of Maris from Niles about what is wrong about her. This method is used again when Martin meets the girl he has been watching from across the street via his telescope.
The only television show to date that has won five consecutive "Outstanding Comedy Series" EMMY awards.
The show was originally written with Frasier as an only child (references had already been made to this in Cheers, but one of the producers saw a headshot of David Hyde Pierce and commented that he looked exactly like Kelsey Grammer did when he first started to appear on Cheers. Presumably as a nod to this, in Season's Two's "The Show Where Sam Shows Up", one of the first things Sam Malone says when he first meets Niles is how Niles looks exactly like Frasier did when he first knew him back in Boston.
Kelsey Grammer has said that "The Show Where Diane Comes Back" is one of his favorite episodes. On Cheers, Shelley Long didn't like the Frasier character and lobbied hard to get Grammer removed from the show. The producers disagreed, noting that the audience liked him. When Long's character of "Diane Chambers" appeared on this show, Grammer said the episode was an opportunity for him and Long to make peace with each other.
The season 4 episode "Head Game" only featured Frasier for the first few minutes, and the rest of the episode is entirely centered around Niles. This role should have been written for Frasier, but Kelsey Grammer wasn't available as he was being treated for his addiction problems, so it was re-written for Niles instead. This is also the reason why the plot involves Niles filling in for Frasier on his radio show, because the show is integral to the plot.
In "The Harassed" (2003) Frasier and Julia Wilcox are having a heated argument, during which Frasier asks Julia "Are you as turned on as I am?" In the Cheers episode "Showdown - Part 2" Sam and Diane are having a similarly big argument. During this argument Sam asks the exact same question, to which Diane replies "More!" and they kiss. The episode aired in 1983, and as an in-joke Bulldog later criticizes Frasier's rather dated choice of line by saying that no one has used the term "turned on" for 20 years.
Frasier's apartment set occupies the same soundstage at Paramount Studios that housed the set of Cheers for so many years.
According to Lisa Maxwell, she auditioned for the role of Daphne. But to a misunderstanding with her agent, she under the impression that she was already cast in the role and did not know it was an audition. She criticized the script and made suggestions on improving it which the show's writers did not like so she did not get the part.
Frasier's radio producer Roz Doyle was named after the late TV producer Roz Doyle as a way to honor her memory. Doyle was a producer on "Wings" which was created by the same creative team as Frasier.
In the premiere episode of the sixth season, the show took over the time slot previously occupied by "Seinfeld" (1989). The episode opens with Frasier auditioning for a TV show after being fired from his radio show, and his opening speech is a reference to the acquisition of "Seinfeld"'s slot: "Before we begin, I'd like to say how honored I am to be taking over this slot. Obviously, I have some rather big shoes to fill - my predecessor here was much beloved. But I have never been one to shrink from a challenge and I'm sure we'll enjoy many happy years here together in my new home."
The show's theme song, "Tossed Salad & Scrambled Eggs", composed by Darryl Phinnessee and Bruce Miller, was performed by star Kelsey Grammer. Phinnessee was not allowed to include direct references to psychiatry, radio or Frasier. He wrote the lyric "tossed salads and scrambled eggs" because they are "mixed up" like Frasier's patients. "The blues a-calling" refers to the people calling Frasier's radio show with their problems. Miller wanted Mel Tormé to sing the theme but the producers wanted Grammer. Grammer sang multiple versions which are rotated throughout the series.
Series Executive Producer David Angell and his wife were on board one of the airplanes that hit the World Trade Center in New York City during the terrorist attacks on 11 September 2001.
It is said in Season 8 that Daphne (Jane Leeves) has lost 9 lbs 12 oz at the health spa. This is a reference/inside joke to the fact that Jane Leeves was away on maternity leave, and her daughter Isabella's birth weight was 9 lbs 12 oz. Therefore the amount of weight that Daphne lost while being away from the show was the same amount Jane Leeves lost while being away from the show as a result of giving birth.
David Hyde Pierce has said that, prior to this series, he had no strong interest in either wine or opera. Ironically, he was introduced to both by John Mahoney, whose Martin Crane character eschews anything cultured.
As of 2004, Kelsey Grammer will have been playing the character of Frasier Crane for 20 consecutive years. This is one of the longest periods that an actor has played the same character on American prime time (non-soap opera) television. Fellow record holders include James Arness of Gunsmoke who also played Marshall Dillon for 20 years straight.
In the 11th season (2004), guest star Laurie Metcalf, playing Frasier's first wife, Nanette, who a children's entertainer, asked Frasier, "Do you know what it's like to play the same character for twenty years?" Kelsey Grammer had been playing Frasier Crane since 1984.
The glass sculpture to the right of Frasier's fireplace is a piece made by Dale Chihuly, a well-known glass sculptor whose studio is based in Tacoma, Washington (just south of Seattle).
The sculpture above Frasier's fireplace is by Laddie John Dill, a sculptor based in Los Angeles.
After Cheers had finished filming, the bar was taken down and the sets for this show were built over it.
In an episode of Cheers, Frasier tells the gang that his father was a research scientist and has passed away. When Ted Danson guest-starred on the show in 1995 as Sam Malone, the continuity error was explained away by having Frasier admit that he made up the story because "We'd had a fight and I was mad at him."
Bebe Neuwirth was offered a regular role on this series as Lilith but she turned it down so she could return to the Broadway stage. She appears only as a guest star.