The TV series was loosely based on a 1950 film of the same name.
Wayde Preston walked off the set after a dispute with producers. He was replaced by Donald May, who was introduced as Christopher Colt's cousin, Sam Colt Jr. Preston and the studio would eventually settle their differences, and he returned for what would turn out to be the final episodes, which featured both Colt cousins.
This was one of three different series to have Adam West appear as Doc Holliday. The other two were Lawman and Sugarfoot.
In the "Hadley's Hunters" episode of Maverick Bart Maverick walks into an office and finds Christopher Colt's satchel on a desk, and his gun belt hanging on a wall. This was an insider reference to the series being canceled at the end of the previous season.