The theme song is a variation of DJ Mark The 45 King's production of Queen Latifah's "Dance for Me."
Clarissa's nickname by her Dad is "Sport".
In the episode called "Haunted House", Clarissa's aunt, Aunt Mafalda comes from Ottawa, Canada to visit the family. Elizabeth Tess, who portrays Clarissa's mother Janet Darling was born in Toronto, Canada.
In the pilot episode, Marshall says after Sam goes out the kitchen window "Why doesn't that boy ever use the door?" Sam during most of the show's run, used Clarissa's bedroom window to enter the house.
During the run of the show, several changes are added to the house/set. Clarissa's bedroom window gets a window seat, a back staircase is added in the kitchen as well as a window seat in the kitchen, a guest room and Marshall's study are added, and the front staircase railing was painted white.
When Clarissa's TV tuner kit pulls in the "Soviet Home Shopping Channel" in the middle of what appears to be a potato advertisement, the bottom of the screen actually says "Glastnost! Perestroika!" in faux-Cyrillic.
The title is based upon Henny Youngman's signature joke, "Now take my wife. Please!"