- In an NPR radio interview, Matt Damon said that Steven Soderbergh, to get Mark Whitacre's final apology to the judge just right, directed Damon to perform the lines as if he were accepting an Academy Award. (Damon said it was an example of "perfect direction".)
- The address to the Swedish bio-chem firm that Whitacre used to steal money from ADM happens to be the address to a real bio-chem firm in Lund (Novozymes Biopharma AB). Novozymes had nothing to do with the events depicted in the film though, as the company was founded in 2000.
- This story was the subject of the 9-15-2000 episode (#168) of This American Life entitled "The Fix is In."
- To prepare for the role of the overweight character Mark Whitacre, Matt Damon purposely gained weight prior to filming. He did this by eating lots of hamburgers, pizza, and dark beer, which he described in an interview as being "really, really, really fun."